• Alfons C M van den Bergh, Michiel A Schoorl, Robin P F Dullaart, Anton M van der Vliet, Ben G Szabó, Cees A ter Weeme, and Jan-Willem R Pott.
• Department of Radiation Oncology, University Hospital Groningen, PPO Box 30.001, 9700 RB Groningen, The Netherlands. a.c.m.van.den.bergh@rt.azg.nl
• J Neuroophthalmol. 2004 Sep 1; 24 (3): 200-5.

AbstractThe incidence of radiation optic neuropathy (RON) after external photon beam radiation therapy for nonfunctioning pituitary adenoma (NFA) is not well-studied. Retrospective review of ophthalmological and imaging data in 72 patients with NFA treated between 1985 and 1998 with external beam radiation therapy after surgery Clinical follow-up after radiation therapy had to be at least 18 months. RON was defined as a sudden and profound irreversible visual loss affecting the optic nerve or chiasm A review of previously published cases of RON was then performed. In our cohort, no patient had RON. A total of 11 adequately documented series reports of RON were found in the medical literature on radiation-treated NFAs. The incidence of RON in NFA from these series is 0.53% (95% CI, 0.26%-0.96%). An additional 14 single RON cases have been reported, bringing the total of adequately documented RON cases to 25. RON is a rare complication after external beam radiation therapy for NFA.

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