• Fuping Zhu, Qing Chang, Shigang Duan, and Weiye Leng.
• Department of General Surgery, The Ninth People's Hospital of Chongqing, Chongqing, China.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e23678e23678.

BackgroundHepatocellular carcinoma (HCC) is one of the most common type of malignant tumors in adults, and is the most common cause of death in people with cirrhosis. Both laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) are radical treatments for small HCC. However, there is no international standard for the treatment of small HCC, and it is still controversial to choose LH or RFA in treating small HCC. We try to carry out a randomized, controlled, prospective study to compare the the short-term and long-term effects and safety of LH versus RFA in the treatment of small HCC.MethodsThis study is a single-center, evaluator-blinded, randomized, controlled clinical trial (RCT). The patients will be randomly divided into RFA group and LH group in a 1:1 ratio according to a computer-generated randomization list. Postoperative complications rates, Alpha fetoprotein (AFP), hospital stay, 1, 2, 3-year overall survival (OS) rates, disease-free survival (DFS) rates and all possible adverse events will be recorded. Statistical analyses will be performed with SPSS v22.0 software.ConclusionsThe study will compare the the short-term and long-term effects and safety of LH versus RFA in the treatment of small HCC.Osf Registration Numberdoi: 10.17605/OSF.IO/HNX2T.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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