• Chunmian Chen, Yafang Yang, Xinwu Ye, Yulian Jin, Ziyao Cai, and Jie Zheng.
• Deanery.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e23876e23876.

ObjectivesTo assess the effect of aerobic exercise (AE) on cognition function in people with schizophrenia (SZ) during daily nursing.MethodsThe literature search will be conducted via PubMed, Embase, Cochrane Library, and Web of Science. Weighted mean difference (WMD) or standardized mean difference (SMD) and 95% confidence intervals (CIs) will be adopted to calculate the association between AE and cognitive function in patients with SZ. Publication bias will be performed by Begg test. When there is publication bias, "cut-and-fill method" will be adopted to adjust publication bias. Sensitivity analysis will be used to test the stability of the result. When the heterogeneity is large (I2 ≥ 50%), meta regression will be used to explore the source of inter-study heterogeneity. When the heterogeneity is large (I2 ≥ 50%) and the results are statistically significant (P < .05), age, sex, duration of disease, duration of intervention, amount of exercise per week, improvement of cardiopulmonary health, and other factors will be sub-analyzed.ConclusionThis meta-analysis will evaluate the impact of aerobic exercise on cognitive function in patients with SZ during daily nursing on the basis of existing evidence.Osf Registration Number10.17605/OSF.IO/C8ABX.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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