• Wan-Qiang Chen, Fang-Fang Wu, Hong-Bo Lv, Wen-Ting Xing, Qi Liu, Jun-Ping Liu, Yong-Gui Ge, and Ya-Qin Lu.
• Department of Rehabilitation, The First Hospital of Lanzhou University.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e23945e23945.

BackgroundAlzheimer disease (AD) is a progressive neurodegenerative disease characterized by impaired memory and cognitive judgment. It is the leading cause of dementia in the elderly, and its high morbidity and mortality have also brought a significant social burden. So far, there is no method can completely cure Alzheimer's dementia, but there are many non-drug treatments that have been praised by people, especially the cognitive behavioral therapy proposed in recent years. The main purpose of this article is to evaluate the effect of cognitive behavioral therapy on the cognitive function improvement of patients with Alzheimer's dementia.MethodsWe did a network meta-analysis to identify both direct and indirect evidence in relevant studies. A systematic literature search will be performed in the Cochrane Library, PubMed, and EMBASE from inception to October 2020. We extracted the relevant information from these trials with a predefined data extraction sheet and assessed the risk of bias with the Cochrane risk of bias tool.The outcomes investigated were Mini-Mental State Examination and AD Assessment Scale-Cognitive section scores. We did a pair-wise meta-analysis using the fixed-effects model and then did a random-effects network meta-analysis within a Bayesian framework. The = the Assessment of Multiple Systematic Reviews-2 scale, Preferred Reporting Items for Systematic Reviews and Meta-Analyses scale and Grading of Recommendations Assessment, Development and Evaluation were used to assess the quality and evidence grade of the literature. General characteristics of the eligible randomized controlled trials will be summarized and described. Meanwhile, The ADDIS software will be used to perform the network meta-analysis, and the result figures will be generated by STATA 15.0 software.ResultsUsing the draft search strategy of databases and after screening,7 randomized controlled trials met the a priori criteria and were included. This network mate-analysis will be published in a peer-reviewed journal.ConclusionOur study will provide evidence for cognitive behavioral intervention in AD patients. And provide recommendations and guidelines for the clinic.Protocol RegistrationINPLASY2020110052.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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