• Weirong Mao, Shengzhi Zhang, Lanying Wang, and Shaohua Shen.
• Yuyao People's Hospital, Yuyao, Zhejiang province, China.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e23954e23954.

BackgroundThe incidence of gestational diabetes is increasing, which not only cause adverse pregnancy outcomes, but also increases the risk of diabetes for pregnant women and their children. Insulin is the gold standard for the treatment of gestational diabetes, but there are some disadvantages, such as poor patient compliance. Metformin has been used in the treatment of gestational diabetes, but the evaluation of its efficacy and safety is lack of reliable evidence-based medicine evidence. The purpose of this study was to systematically investigate the efficacy and safety of metformin in the treatment of diabetic gestational diabetes.MethodsComputer searches China National Knowledge Infrastructure, Wanfang, Vipu Information Chinese Journal Service Platform and China Biomedical Database, PubMed, Embase, Web of Science, the Cochrane Library from the establishment of the database to November 2020, randomized controlled clinical trials of metformin in the treatment of gestational diabetes mellitus were conducted in English and Chinese. Two researchers independently carried out data extraction and literature quality evaluation on the quality of the included study, and the included literature was analyzed by Meta using RevMan5.3 software.ResultsIn this study, the efficacy and safety of metformin in the treatment of diabetic gestational diabetes were investigated by evaluating the outcome indicators of pregnant women and newborn babies respectively.ConclusionThis study will provide reliable evidence for the clinical application of metformin in the treatment of diabetic gestational diabetes.Ethics And DisseminationThe private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Osf Registration NumberDOI 10.17605/ OSF.IO / 7RB95.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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