• Wei Wang, Ying He, Dou Wen, Shangshang Jiang, and Xiaodong Zhao.
• Dongzhimen Hospital, Beijing University of Chinese Medicine.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e23966e23966.

BackgroundUlcerative colitis (UC) belongs to chronic colitis whose etiology and pathogenesis still have remained unclear. Hyperbaric oxygen therapy (HBOT) has been demonstrated to be effective for UC therapy. Still, evidence of its efficacy and safety is inconclusive. The purpose of the protocol is to evaluate the efficacy and safety of HBOT in UC therapy.MethodsThis systematic review will retrieve studies that meet the requirements in Embase, MEDLINE, PubMed, Web of Science, Cochrane Library Central Register of Controlled Trials, the Chinese Biomedical Literature Database (CBM), China national knowledge infrastructure database (CNKI), Wei Pu database, Wan fang database, SinoMed, Google scholar, and Baidu Scholar from their inception to November 2020. Two authors are to be independent in their article selection, data collection, and research quality assessments. The primary outcome is the clinical effectiveness. And the secondary outcomes will include 4 criteria. RevMan 5.3 software will be utilized for analysis of the data.ResultsThe results of this study are to be submitted via a peer-reviewed journal.ConclusionsThe study is to assess the effectiveness and safety of HBOT for UC and provide valid and reliable evidence regarding HBOT for UC.Inplasy Registration NumberINPLASY2020100118.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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