• Jae Taek Hong, Jin-Hwan Kim, Keun-Su Kim, Chong-Suh Lee, Hyun-Chul Shin, Woo-Kyung Kim, Joo-Han Kim, Jung-Kil Lee, In-Soo Kim, Yoon Ha, Soo-Bin Im, Sang Woo Kim, In-Ho Han, Jun-Jae Shin, ByeongCheol Rim, Kyung-Soo Suk, Jin-Hyok Kim, Ye-Soo Park, Bong-Soon Chang, Deuk Soo Jun, Young-Hoon Kim, Jung-Hee Lee, Woo-Kie Min, Jung Sub Lee, Si-Young Park, In-Soo Oh, Jae-Young Hong, Bo-Jeong Seo, Young-Joo Kim, and Juneyoung Lee.
• Department of Neurosurgery, The catholic university of Korea, St. Vincent's hospital & Eunpyung St. Mary's Hospital, Suwon Department of Orthopedic Surgery, Inje University Ilsan Paik Hospital, Gyeonggi-do Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health System Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine Department of Neurosurgery, Kangbuk Samsung Hospital, Seoul Department of Neurosurgery, Gachon University Gil Medical Center, Incheon Department of Neurosurgery, Korea University Guro Hospital, Seoul Department of Neurosurgery, Chonnam National University Hospital, Kwangju Department of Neurosurgery, Keimyung University Dongsan Hospital, Daegu Department of Neurosurgery, Severance Hospital, Yonsei University Health System, Seoul Department of Neurosurgery, Soonchunhyang University Hospital Bucheon, Gyeonggi-do Department of Neurosurgery, Yeungnam university Hospital, Daegu Department of Neurosurgery, Pusan National University Hospital, Busan Department of Neurosurgery, Inje University Industry Academic Cooperation Foundation, Wonju, Korea Department of Neurosurgery, Sun Medical Center, Kerala, India Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University Health System Department of Orthopedic Surgery, Inje University Sanggye Paik Hospital, Seoul Department of Orthopedic Surgery, Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do Department of Orthopedic Surgery, Seoul National University Hospital, Seoul Department of Orthopedic Surgery, Gachon University Gil Medical Center, Incheon Department of Orthopedic Surgery, Seoul St. Mary's Hospital of the Catholic University of Korea Department of Orthopedic Surgery, Kyung Hee University Hospital, Seoul Department of Orthopedic Surgery, Kyungpook National University Hospital, Daegu Department of Orthopedic Surgery, Pusan National University Hospital, Busan Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul Department of Orthopedic Surgery, Incheon St. Mary's Hospital of the Catholic University of Korea, Incheon Department of Orthopedic Surgery, Korea University Ansan Hospital, Gyeonggi-do Outcomes Research/Real World Data, Corporate Affairs & Health and Value, Pfizer Pharmaceuticals Korea Ltd. Department of Biostatistics, College of Medicine, Korea University, Seoul, Republic of Korea.
• Medicine (Baltimore). 2018 Aug 1; 97 (35): e11919.

AbstractA number of studies have demonstrated an association of neuropathic pain and chronic low back pain (CLBP), but the outcome difference in each medical management is poorly understood. This study is aimed to investigate treatment patterns of neuropathic pain in CLBP patients and to explore patient-reported outcomes (PROs) including quality of life (QoL) and functional disability by treatment patterns.Data were extracted from the neuropathic low back pain (NLBP) outcomes research. It was a multicenter and cross-sectional study in which 1200 patients were enrolled at 27 general hospitals, from 2014 to 2015. Of total, 478 patients classified as neuropathic pain were used for this subgroup analysis. The patients were divided into 2 groups according to treatment patterns (with vs. without the targeted therapy [TT] of neuropathic pain). Demographic and clinical features were collected by chart reviews and PROs were measured by patient's survey. QoL was assessed by EuroQoL 5-dimension (EQ-5D) questionnaire. Functional disability was measured by the Quebec Back Pain Disability Scale (QBPDS). Multiple linear regression analyses were conducted to compare the PROs between TT group and non-targeted therapy (nTT) group.Among the NLBP patients (mean age 63years, female 62%), EQ-5D index, EuroQoL-Visual Analog Scale (EQ-VAS), and QBPDS Scores (mean ± standard deviation) were 0.40 ± 0.28, 54.98 ± 19.98, and 46.03 ± 21.24, respectively. Only 142 (29.7%) patients had pharmacological TT of neuropathic pain. Univariate analyses revealed no significant mean differences between TT group and nTT group in the EQ-5D index (0.41 ± 0.27 and 0.39 ± 0.28), EQ-VAS (56.43 ± 18.17 and 54.37 ± 20.69), and QBPDS (45.31 ± 21.32 and 46.31 ± 21.24). After adjustment with covariates, TT group had higher scores of EQ-5D index (β = 0.07; P < 0.01) and EQ-VAS (β = 4.59; P < 0.05) than the nTT group. The TT group's QBPDS score was lower than the nTT group, although its statistical significance still has not been reached (β = -4.13; P = 0.07).We found that considerable proportion of the NLBP patients remains untreated or undertreated. Although TT group had significantly better QoL than nTT group, only 29.7% of NLBP patients had pharmacological TT. Therefore, clinicians should consider using TT for better QoL of neuropathic pain patients.

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