• Aitor Uribarri, Iván J Núñez-Gil, Alvaro Aparisi, Victor M Becerra-Muñoz, Gisela Feltes, Daniela Trabattoni, Inmaculada Fernández-Rozas, María C Viana-Llamas, Martino Pepe, Enrico Cerrato, Thamar Capel-Astrua, Rodolfo Romero, Alex F Castro-Mejía, Ibrahim El-Battrawy, Javier López-País, Fabrizio D'Ascenzo, Oscar Fabregat-Andres, Alfredo Bardají, Sergio Raposeiras-Roubin, Francisco Marín, Antonio Fernández-Ortiz, Carlos Macaya, Vicente Estrada, and HOPE COVID-19 Investigators.
• Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain. auribarrig@gmail.com.
• J. Nephrol. 2020 Aug 1; 33 (4): 737-745.

BackgroundCoronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain.MethodsAnalysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m2, eGFR 30-60 mL/min/1.73 m2 and eGFR < 30 mL/min/1.73 m2).Results758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR < 60 mL/min/1.73 m2). These patients received less frequently pharmacological treatment with hydroxychloroquine or antivirals and had a greater number of complications such as sepsis (11.9% vs 26.4% vs 40.8%, p < 0.001) and respiratory failure (35.4% vs 72.2% vs 62.0%, p < 0.001) as well as a higher in-hospital mortality rate (eGFR > 60 vs eGFR 30-60 vs and eGFR < 30, 18.4% vs 56.5% vs 65.5%, p < 0.001). In multivariate analysis: age, hypertension, renal function, 02 saturation < 92% and lactate dehydrogenase elevation on admission independently predicted all-cause mortality.ConclusionsRenal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings.

35 keywords...

hide…