• Pharmacotherapy · Jul 1995

    Train-of-four: to use or not to use.

    • S J Tschida, L L Hoey, D Mather, and K Vance-Bryan.
    • College of Pharmacy, University of Minnesota, Minneapolis, USA.
    • Pharmacotherapy. 1995 Jul 1; 15 (4): 546-50.

    AbstractA pattern of nerve stimulation called train-of-four (TOF) is frequently used to monitor therapy with nondepolarizing neuromuscular blocking agents in patients treated in intensive care units. Based on our experience with TOF monitoring in several critically ill patients, we believe its application as an indicator of neuromuscular blockade may be problematic in this setting.

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