• Nobuyuki Takahashi, Kazuaki Tanabe, Takashi Sugamori, Masatake Sato, Jun Kitamura, Hidetoshi Sato, Hiroyuki Yoshitomi, Yutaka Ishibashi, and Toshio Shimada.
• 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp
• Med. Sci. Monit. 2011 Jul 1; 17 (7): CS81-4.

BackgroundTakayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.Case ReportIn this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.ConclusionsWe present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

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