• Yuval Krieger, Yaron Shoham, Alexander Bogdanov-Berezovsky, Eldad Silberstein, Amiram Sagi, Avraham Levy, Nir Rosenberg, Guy Rubin, Dana Egozi, Yehuda Ullman, Josef Haik, and Lior Rosenberg.
• Harefuah. 2016 May 1; 155 (5): 281-5, 323, 322.

IntroductionEarly removal of burn eschar is a cornerstone of burn care. The most commonly practiced eschar removal technique for deep burns in modern burn care is surgical debridement but this technique is associated with surgical burden and leads to unnecessary excision of viable tissue.GoalsTo review 30 years of research and development of an enzymatic debridement agent for burns.MethodsStudies performed during the last 30 years are reviewed in this manuscript.ResultsPatients who underwent enzymatic debridement had a significantly shorter time to complete debridement, the surgical burden was significantly lower, hand burns did not necessitate escharotomy, and the long term results were favorable.DiscussionEarly enzymatic debridement leads to an efficient debridement, preservation of viable tissue, a reduction in surgical burden and favorable long term results.ConclusionWe believe early enzymatic debridement will lead to better care for burn victims and perhaps, even to a paradigm shift in the treatment of burns.

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