• Taiwan J Obstet Gynecol · Oct 2017

    The role of resveratrol on full - Thickness uterine wound healing in rats.

    • Oya Sayin, Serap Cilaker Micili, Asli Goker, Gonca Kamaci, Bekir Ugur Ergur, Osman Yilmaz, and Gul Guner Akdogan.
    • Research Laboratory, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey. Electronic address: oya.sayin@deu.edu.tr.
    • Taiwan J Obstet Gynecol. 2017 Oct 1; 56 (5): 657-663.

    ObjectiveHealing of the uterus after cesarean section and myomectomy operation is clinically important. In this study, we aimed to investigate the effects of resveratrol (3,5,4'-o-trihydroxystilbene) on the wound healing process of the uterus in rats treated with resveratrol following full thickness injury of the uterus.Materials And MethodsTwenty-one female wistar albino rats were divided randomly into three groups (1) control group with no intervention (2) injury group with uterine full thickness injury (3) resveratrol group with uterine full thickness injury and treated with resveratrol. Resveratrol was injected by oral gavage at the doses of 0.5 mg/kg/day for 30 days following uterine full thickness injury. Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) distributions were assessed using the immunohistochemical methods in tissue and ELISA methods in the tissue homogenate. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were evaluated with colorimetric method and malondialdehyde (MDA) levels also were measured using high performance liquid chromatography in the tissue homogenate. The effects of resveratrol on the uterine histology also were evaluated histologically with the light microscopy.ResultsHistological evaluation and immunohistochemical evaluations showed that treatment with a resveratrol significantly increased the thickness of the uterine wall and VEGF expression and decreased expression PDGF during wound healing. Biochemically, GPx and SOD activities were increased significantly after treatment with resveratrol. Additionally, resveratrol administration decreased MDA levels.ConclusionThese results showed that the antioxidant effects of resveratrol has been shown to have a positive influence on wound healing of the uterus.Copyright © 2017. Published by Elsevier B.V.

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