• Valentina E Di Mattei, Letizia Carnelli, Paola Taranto, Martina Mazzetti, Gaia Perego, Sara Rottoli, Rancoita Paola M V PMV University Centre of Statistics in Biomedical Sciences CUSSB, Vita-Salute San Raffaele University, Milan, Italy., Alice Bergamini, Micaela Petrone, Emanuela Rabaiotti, Giorgio Candotti, and Massimo Candiani.
• School of Psychology, Vita-Salute San Raffaele University, Milan, Italy.
• Support Care Cancer. 2020 Nov 1; 28 (11): 5343-5351.

PurposeChemotherapy-induced nausea (CIN) is a relevant problem for gynaecological cancer patients. The evaluation of CIN is a key aspect in its management, along with the identification of associated risk factors. The objective of the study was to compare different measurements of nausea and to investigate personal risk factors in CIN development.MethodEighty-one women treated for gynaecological cancers took part. The presence of CIN was evaluated using the MASCC Antiemesis Tool (MAT) and a patient's report to clinicians at the subsequent chemotherapy cycle. Personal risk factors were assessed using the State-Trait Anxiety Inventory and a self-report questionnaire.ResultsThe study shows that the agreement between patients' assessment of CIN with MAT and what they referred to clinicians was only moderate for acute nausea (Cohen's Kappa = 0.55; p < 0.001), while good for delayed nausea (Cohen's Kappa = 0.68; p < 0.001). At multiple logistic regression analysis, younger age, anticipatory nausea, patient medium-high expectations of CIN, and parity emerged as risk factors for the development of acute nausea (p = 0.0087, 0.0080, 0.0122 and 0.0021, respectively). Patient medium-high expectations of CIN and being single resulted to be risk factors for delayed nausea (p = 0.0397 and 0.0024, respectively).ConclusionsOur findings confirm that personal factors contribute to individual differences in the development of CIN; moreover, we highlight the importance of CIN evaluation by clinicians, underlining the need to use reliable instruments.

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