• Wietske Hermes, Corine M Koopmans, Maria G van Pampus, Arie Franx, Kitty W M Bloemenkamp, Joris van der Post, Martina Porath, Jouke T Tamsma, Ben W Mol, and Christianne J M de Groot.
• Department of Obstetrics and Gynecology, Medical Center Haaglanden, The Hague, The Netherlands; Department of Obstetrics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: herwie@mchaaglanden.nl.
• Eur. J. Obstet. Gynecol. Reprod. Biol. 2013 Nov 1; 171 (1): 30-4.

ObjectiveCardiovascular disease (CVD) is the leading cause of death in women in the western world. Several studies have described the association between hypertensive pregnancy disorders and CVD in later life. Our aim was to compare postpartum cardiovascular risk factors in women who had a shorter and women who had a longer exposure to endothelial activation during their term hypertensive pregnancy.Study DesignWe studied a subsample of women with pregnancy-induced hypertension or mild preeclampsia at term, who had participated in the randomized HYPITAT trial comparing induction of labour (IOL cohort) (n=110) or expectant monitoring (EM cohort) (n = 91). We assessed, 2.5 years postpartum, cardiovascular risk factors, i.e. blood pressure, anthropometrics, glucose, HbA1C, insulin, HOMA score, total cholesterol, HDL cholesterol, triglycerides, high sensitive CRP, micro-albumin and metabolic syndrome, and compared these risk factors between the induction and expectant groups.ResultsThe mean time from randomization to delivery was 3.3 days in the induction group and 10.3 days in the expectant group (p<.001), generating a difference in exposure of 7 days. After a mean follow-up period of 2.5 years, the prevalence of hypertension (IOL 34%; EM 37%, p = .66) and metabolic syndrome (IOL 26%; EM 27%, p = 1.0) was similar in both groups. Furthermore, systolic and diastolic blood pressure, BMI, waist circumference, glucose, HbA1C, insulin, HOMA score, lipids, HsCRP-levels and micro-albumin were all comparable between women who had induction of labour and those who had expectant monitoring.ConclusionIn women with hypertensive disorders in pregnancy at term, induction of labour does not affect the clinical and biochemical cardiovascular profile at 2.5 years postpartum.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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