• Neuromodulation · Feb 2022

    Review

    Safety and Feasibility of Nucleus Accumbens Surgery for Drug Addiction: A Systematic Review.

    • Paula Alejandra Navarro, Thiago Paranhos, Eduardo Lovo, Ricardo De Oliveira-Souza, Alessandra A Gorgulho, Antônio De Salles, and LópezWilliam Omar ContrerasWOCGrupo de investigación NEMOD, división de neurocirugía funcional, departamento de neurocirugía, clínica FOSCAL, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia. Electronic address: wcontreras127@unab.edu.co..
    • Grupo de investigación NEMOD, división de neurocirugía funcional, departamento de neurocirugía, clínica FOSCAL, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
    • Neuromodulation. 2022 Feb 1; 25 (2): 171-184.

    BackgroundSubstance addiction encompasses the incapacity to discontinue urgent drug use; many severely disabled patients might be considered appropriate candidates for surgery due to the high rates of relapse despite conservative treatment. A crucial finding in the brain of these patients is increased extracellular concentrations of dopamine in the nucleus accumbens (NAcc).ObjectivesTo determine the efficacy and safety of NAcc surgery for the treatment of substance dependence.Materials And MethodsAdhering to PRISMA guidelines, we performed a systematic review to identify all original studies in which NAcc surgery was performed to treat relapsing drug addiction with a minimum follow-up of six months. From database inception to April 10, 2020, we searched PubMed, Scopus, and LILACS. Two reviewers independently selected studies and extracted data. The main outcome was the relapse rate. The GRADE methods were applied to evaluate the quality of evidence. This study was registered with PROSPERO CRD42020177054.ResultsFifteen studies involving 359 participants met inclusion criteria; eight (56%) included NAcc deep brain stimulation (DBS) in 13 patients with addiction for alcohol (N = 6, 46.1%), opioid (N = 4, 30.7%), and nicotine (N = 3, 15.3%); seven studies (N = 346, 44%) performed NAcc radiofrequency (RF) ablation for opioid (N = 334) and alcohol (N = 12) dependence. Relapse rates were 38.4% for DBS and 39% for RF ablation.ConclusionsDespite available studies reporting a benefit in the treatment of drug addictions with NAcc surgery, this systematic review stresses the need for carefully planned prospective studies in order to further address the efficacy and indications.Copyright © 2021. Published by Elsevier Inc.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…