• Rania A Galhom, Hoda H Hussein Abd El Raouf, and Mona H Mohammed Ali.
• Human Anatomy and Embryology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address: rania-galhom@hotmail.com.
• Biomed. Pharmacother. 2018 Dec 1; 108: 1365-1375.

BackgroundSpinal cord injury is a considerable health impact accompanied with physical, psychological and economic burden. Bone marrow derived mesenchymal stromal cells (BM-MSCs) transplantation was found to produce neuronal regenerative effects. Schwann-like cells differentiated from BM-MSCs have myelin-forming ability.Aim Of The WorkTo compare the ability of BM-MSCs versus Schwann like cells to promote recovery of spinal cord injury.Material And MethodsAdult male albino rats were used throughout the study. BM-MSCs were harvested from femora of rats. Sciatic nerves were extracted and used in the preparation of the induction culture medium for differentiation of BM-MSCs into Schwann-like cells. Rats were divided into control, spinal cord injured (SCI), spinal cord injured plus BM-MSCs transplantation (BM-MSC) and spinal cord injured plus Schwann-like cells transplantation (Sn) groups. BBB scale assessment was performed before and after SCI in all rats. Rats were euthanized at the end of the 7th week and spinal cords were dissected and processed for light and transmission electron microscopic examinations.ResultsSpinal cord sections of SCI group revealed cavitation, necrosis and demyelination. BM-MSC and Sn groups showed both functional and structural improvement compared to SCI group with better BBB score and histopathological features in the BM-MSC group and more expression of S100 in the Sn group.ConclusionTransplantation of BM-MSCs and Schwann-like cells improved the structural and functional alterations of spinal cord injury with better improvement in BM-MSC group.Copyright © 2018 Elsevier Masson SAS. All rights reserved.

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