• Wei-Na Du, Ying Zhang, Yong Yu, and Ru-Min Zhang.
• Department of Critical Care Medicine, Huantai County People's Hospital, Zibo, China.
• Int. J. Clin. Pract. 2021 Aug 1; 75 (8): e14031.

ObjectiveThe ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients also have abnormal D-dimer concentration in the serum, but the results are controversial.MethodA meta-analysis first aims to explored the connection between D-dimer concentration and COVID-19 patients.ResultsOur results found a significant relationship between D-dimer and COVID-19, with a pooled OR of 1.90 (95% CI: 1.32-2.48; P < .001). The pooled data were calculated with the REM as a high heterogeneity within the studies. The sensitivity analysis results showed that the WMD ranged from 1.69 (95% CI: 1.15 to 2.23) to 2.06 (95% CI: 1.51 to 2.62) and there was no publication bias.ConclusionsOur meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. Meanwhile, the severe COVID-19 patients tend to have a higher concentration of D-dimer when compared with non-severe patients.Review CriteriaWe used MASH word and searched the online database and followed the inclusion and exclusion standard. The detailed information can be found in the text.Message For The ClinicOur meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. This may be helpful for the clinic COVID-19 patients.© 2021 John Wiley & Sons Ltd.

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