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The Journal of pediatrics · Feb 2011
Case ReportsCyclophosphamide for rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome.
- Ido Paz-Priel, David W Cooke, and Allen R Chen.
- Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD 21231, USA. ipazpri1@jhmi.edu
- J. Pediatr. 2011 Feb 1; 158 (2): 337-9.
AbstractPatients with rapid-onset obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor syndrome have poor long-term outcomes. We report a patient who was treated successfully with high-dose cyclophosphamide immunoablation. This experience offers a novel therapeutic approach and an indirect insight into the underlying pathogenesis of this syndrome.Copyright © 2011 Mosby, Inc. All rights reserved.
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