• Martina Mosing, Charlotte Marly-Voquer, Paul MacFarlane, David Bardell, Stephan H Böhm, Regula Bettschart-Wolfensberger, and Andreas D Waldmann.
• Equine Department, Section of Anaesthesiology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
• Vet Anaesth Analg. 2017 Jan 1; 44 (1): 127-132.

ObjectiveTo evaluate the regional distribution of ventilation in horses during spontaneous breathing and controlled mechanical ventilation (CMV) using electrical impedance tomography (EIT).Study DesignProspective, experimental case series.AnimalsFour anaesthetized experimental horses.MethodsHorses were anaesthetized with isoflurane in an oxygen-air mixture and medetomidine continuous rate infusion, placed in dorsal recumbency with an EIT belt around the thorax, and allowed to breathe spontaneously until PaCO2 reached 13.3 kPa (100 mmHg), when volume CMV was started. For each horse, the EIT signal was recorded for at least 2 minutes immediately before (T1), and at 30 (n = 3) or 60 (n = 1) minutes after the start of CMV (T2). The centre of ventilation (CoV), dependent silent spaces (DSS) (likely to represent atelectatic lung areas), non-dependent silent spaces (NSS) (likely to represent lung areas with low ventilation) and total ventilated area (TVA) were evaluated. Cardiac output (CO) was measured and venous admixture and oxygen delivery (DO2) were calculated at T1 and T2. Data are presented as median and range.ResultsAfter the initiation of CMV, the CoV moved ventrally towards the non-dependent lung by 10% [from 57.4% (49.6-60.2%) to 48.3% (41.9-54.4%)]. DSS increased [from 4.1% (0.2-13.9%) to 18.7% (7.5-27.5%)], while NSS [21.7% (9.4-29.2%) to 9.9% (1.0-20.7%)] and TVA [920 (699-1051) to 837 (662-961) pixels] decreased. CO, venous admixture and DO2 also decreased.Conclusions And Clinical RelevanceIn spontaneously breathing anaesthetized horses in dorsal recumbency, ventilation was essentially centred within the dependent dorsal lung regions and moved towards non-dependent ventral regions as soon as CMV was started. This shows a major lack of ventilation in the dependent lung, which may be indicative of atelectasis.Copyright © 2016 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

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