• Karen M L Tan, Anne H Y Chu, See Ling Loy, Victor Samuel Rajadurai, HoClement K MCKM, Yap Seng Chong, Neerja Karnani, Yung Seng Lee, Fabian Kok Peng Yap, and Shiao Yng Chan.
• Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
• Ann Acad Med Singap. 2020 Dec 1; 49 (12): 937-947.

IntroductionThis study examined maternal, delivery and infant factors associated with cord thyroid-stimulating hormone (TSH) concentrations in an Asian population.MethodsThe Growing Up in Singapore Towards healthy Outcomes (GUSTO) study is a mother-offspring birth cohort from 2 major hospitals in Singapore. Cord serum TSH was measured using the Abbott ARCHITECT TSH Chemiluminescent Microparticle Immunoassay and the ADVIA Centaur TSH-3 Immunoassay. After excluding infants with a maternal history of thyroid disease, screening cord TSH results from 604 infants were available for multivariable regression analysis in relation to the factors of interest.ResultsBabies born by vaginal delivery had significantly higher cord serum TSH concentrations than babies born by caesarean section. Cord serum TSH concentrations differed significantly by measurement method. There was no association of cord TSH concentrations with ethnicity, sex, birth weight, gestational age, maternal body mass index, gestational weight gain, gestational diabetes mellitus status and other maternal, delivery and infant factors studied.ConclusionInterpretation of cord serum TSH results may need to take into account mode of delivery and measurement method.

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