• W P J van Oosterhout, E J W van Someren, M A Louter, G G Schoonman, G J Lammers, R M Rijsman, M D Ferrari, and G M Terwindt.
• Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
• Eur. J. Neurol. 2016 Jun 1; 23 (6): 1110-6.

Background And PurposeOur aim was to study not only the prevalence but more importantly the severity and the correlation between sleep quality and restless legs syndrome (RLS) in a large population of well-defined migraine patients as poor sleep presumably triggers migraine attacks.MethodsIn a large cross-sectional and observational study, data on migraine and RLS were collected from 2385 migraine patients (according to the International Classification of Headache Disorders ICHD-IIIb) and 332 non-headache controls. RLS severity (International RLS Study Group severity scale) and sleep quality (Pittsburgh Sleep Quality Index) were assessed. Risk factors for RLS and RLS severity were calculated using multivariable-adjusted regression models.ResultsRestless legs syndrome prevalence in migraine was higher than in controls (16.9% vs. 8.7%; multivariable-adjusted odds ratio 1.83; 95% confidence interval 1.18-2.86; P = 0.008) and more severe (adjusted severity score 14.5 ± 0.5 vs. 12.0 ± 1.1; P = 0.036). Poor sleepers were overrepresented amongst migraineurs (50.1% vs. 25.6%; P < 0.001). Poorer sleep quality was independently associated with RLS occurrence (odds ratio 1.08; P < 0.001) and RLS severity (P < 0.001) in migraine patients.ConclusionRestless legs syndrome is not only twice as prevalent but also more severe in migraine patients, and associated with decreased sleep quality.© 2016 EAN.

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