• Colin Brewer and Emmanuel Streel.
• Retired Psychiatrist and addiction Physician, London, SE1, London, UK.
• Alcohol Alcohol. 2020 Jun 25; 55 (4): 354-356.

AimIn view of the increase in the use of ethanol-containing hand sanitizers throughout the world due to the current COVID-19 pandemic, we wished to review the possible risks to patients treated with disulfiram, following a case report in which an apparent DER (disulfiram-ethanol reaction) was attributed to the cutaneous absorption of alcohol from hand sanitizers as well as by inhalation of vapour.MethodSimple experiments to assess the levels of absorption by each route separately.ResultsOur results strongly suggest that while amounts of alcohol sufficient to cause a DER may be inhaled when hand sanitizers are used in confined spaces, absorption can be avoided by dispersal of the fumes, and absorption from the skin alone does not occur in pharmacologically significant quantities.ConclusionWarnings about absorption of alcohol through the skin from hand sanitizers and products such as perfumes, deodorants and after-shave (whose use is often warned against when disulfiram is prescribed) should be modified accordingly.© The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved.

27 keywords...

hide…