• Surgical infections · Dec 2008

    Necrotizing soft tissue infection.

    • Joseph Cuschieri.
    • Department of Surgery, University of Washington, Seattle, Washington, USA. jcuschie@u.washington.edu
    • Surg Infect (Larchmt). 2008 Dec 1; 9 (6): 559-62.

    BackgroundNecrotizing soft tissue infections (NSTIs) continue to pose major problems in diagnosis and management.MethodsReview of the pertinent English-language literature.ResultsA high index of suspicion and good clinical judgment should be used in conjunction with laboratory and imaging studies in appropriate cases to establish the diagnosis as rapidly as possible. Successful treatment requires early, aggressive surgical debridement of all necrotic tissue, appropriate systemic antibiotic therapy, and supportive care to maintain oxygenation and tissue perfusion.ConclusionsThe mortality rate of necrotizing soft tissue infection remains approximately 25% despite optimal care. Delayed definitive debridement remains the single most important risk factor for death.

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