• Maria J Crespo, Miguel Marrero, Nildris Cruz, Jose Quidgley, Osmar Creagh, Hector Torres, and Karines Rivera.
• Physiology Department, University of Puerto Rico-School of Medicine, San Juan, PR. maria.crespo3@upr.edu
• Diab Vasc Dis Res. 2011 Oct 1; 8 (4): 299-302.

BackgroundPeople with diabetes are at increased risk of cardiovascular (CV) morbidity and mortality during surgery. The most appropriate anaesthetic induction agent for these patients is unknown.Methods And ResultsWe assessed the CV effects of propofol, etomidate and ketamine in streptozotocin (65 mg/kg, IP) diabetic rats. In non-diabetic rats, none of these anaesthetics significantly modified cardiac output, heart rate or stroke volume, but ketamine increased systolic blood pressure (SBP) compared to etomidate and propofol (89.6 ± 2.4 mmHg, vs. 72.7 ± 3.0 and 75.4 ± 1.9; p < 0.05). In diabetic rats, by contrast, cardiac output was lower with ketamine (82.6 ± 14 ml/min) and etomidate (78.2 ± 15.8 ml/min) than with propofol (146 ± 21 ml/min, N = 8, p < 0.01). SBP, however, was higher in the propofol-treated group (93.3 ± 3.4 mmHg, p < 0.05).ConclusionThese results suggest that hyperglycaemia modifies CV responses to induction anaesthetics.

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