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Neuroscience letters · Sep 2019
ReviewGene editing based hearing impairment research and therapeutics.
- Wen Kang, Zhuoer Sun, Xingle Zhao, Xueling Wang, Yong Tao, and Hao Wu.
- Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China; Ear Institute, Shanghai Jiaotong University School of Medicine, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, China.
- Neurosci. Lett. 2019 Sep 14; 709: 134326.
AbstractHearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and have rescued deafness in multiple hereditary murine models. CRISPR-Cas9 and base editors (BEs) are newly developed gene editing technologies that can facilitate gene studies in the inner ear and provide therapeutic approaches for hearing impairment. Here, we present recent applications of gene editing in the inner ear.Copyright © 2019 Elsevier B.V. All rights reserved.
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