• American heart journal · Jan 2008

    Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair.

    • Phalla Ou, David S Celermajer, Odile Jolivet, Fanny Buyens, Alain Herment, Daniel Sidi, Damien Bonnet, and Elie Mousseaux.
    • Department of Pediatric Radiology, Hôpital Necker-Enfants Malades, University Rene Descartes-Paris 5, Paris, France. phalla.ou@nck.ap-hop-paris.fr
    • Am. Heart J. 2008 Jan 1; 155 (1): 187-93.

    BackgroundHypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting.MethodsForty normotensive asymptomatic subjects with successful CoA repair (age 12 +/- 8 years) and 20 age- and sex-matched control subjects underwent detailed magnetic resonance imaging investigation of the thoracic aorta and left ventricle. Aortic distensibility, compliance, and stiffness beta index were calculated in the central (precoarctation) and descending (postcoarctation) aorta. Aortic pulse wave velocity was measured and left ventricular mass was calculated.ResultsCompared to control subjects, CoA subjects had markedly decreased central aortic distensibility (2.8 +/- 0.7 vs 4.2 +/- 0.5 mm Hg(-1) x 10(-3), P < .001) and compliance (1.7 +/- 0.3 vs 2.5 +/- 0.6 mm2 mm Hg(-1), P < .001) and increased stiffness beta index (5.2 +/- 1 vs 2.5 +/- 0.6, P < .001). Pulse wave velocity was also significantly increased in the CoA subjects (4.7 +/- 1.3 vs 3.3 +/- 0.6 m/sec, P < .001). Left ventricular mass index was higher in the CoA subjects (84 +/-11 vs 73 +/-10 g/m2, P = .01) and correlated significantly with aortic stiffness beta index (r2 = 0.8, P < .0001). By contrast, descending aortic characteristics were similar in the CoA and control subjects.ConclusionCentral aortic stiffness is markedly increased and associated with increased left ventricular mass in normotensive young subjects after successful early repair of CoA.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…