• Int. J. Clin. Pract. · Jul 2021

    Eosinopenia is a reliable marker of severe disease and unfavorable outcome in patients with COVID-19 pneumonia.

    • Massimo Cazzaniga, Luca A M Fumagalli, Luciano D'angelo, Mario Cerino, Giulia Bonfanti, Riccardo M Fumagalli, Gianpaolo Schiavo, Cristina Lorini, Elisa Lainu, Sabina Terragni, Marco Chiarelli, Claudio Scarazzati, Claudio Bonato, and Mauro Zago.
    • Ospedale Alessandro Manzoni, Lecco, Italy.
    • Int. J. Clin. Pract. 2021 Jul 1; 75 (7): e14047.

    Background And AimViral pneumonia is the most relevant clinical presentation of COVID-19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVID-19 pneumonia, but its role is poorly investigated. The aim of the present study was to investigate the characteristics and clinical outcomes of patients with COVID-19 pneumonia and eosinopenia.MethodsWe revised the records of consecutive patients with COVID-19 pneumonia admitted to our ER-COVID-19 area in order to compare clinical characteristics and outcomes of patients with and without eosinopenia. We considered the following clinical outcomes: 4-weeks survival; need for intensive respiratory support; and hospital discharge.ResultsOut of first 107 consecutive patients with pneumonia and a positive COVID-19 nasopharyngeal swab, 75 patients showed undetectable eosinophil count (absolute eosinopenia). At 4 weeks, 38 patients (38.4%) had required intensive respiratory treatment, 25 (23.4%) deceased and 42 (39.2%) were discharged. Compared with patients without absolute eosinopenia, patients with absolute eosinopenia showed higher need of intensive respiratory treatment (49.3% vs 13.3%, P < .001), higher mortality (30.6% vs 6.2%, P .006) and lower rate of hospital discharge (28% vs 65.6%, P < .001). Binary logistic regression analyses including neutrophil, lymphocyte, eosinophil, basophil and monocyte counts showed that absolute eosinopenia was an independent factor associated with 4-weeks mortality, need for intensive respiratory support and hospital discharge.ConclusionsAbsolute eosinopenia is associated with clinical outcomes in patients with COVID-19 pneumonia and might be used as a marker to discriminate patients with unfavourable prognosis.© 2021 John Wiley & Sons Ltd.

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