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J. Neurol. Neurosurg. Psychiatr. · Dec 2021
ReviewCalcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects.
- Jason Charles Ray, Mahima Kapoor, Richard J Stark, Shuu-Jiun Wang, Lars Bendtsen, Manjit Matharu, and Elspeth Jane Hutton.
- Neurology, Alfred Health, Melbourne, Victoria, Australia j.ray@alfred.org.au.
- J. Neurol. Neurosurg. Psychiatr. 2021 Dec 1; 92 (12): 1325-1334.
AbstractMigraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
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