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J. Neurol. Neurosurg. Psychiatr. · Sep 2012
Comparative StudyAmyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
- David A Wolk, Zheng Zhang, Sanaa Boudhar, Christopher M Clark, Michael J Pontecorvo, and Steven E Arnold.
- Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. david.wolk@uphs.upenn.edu
- J. Neurol. Neurosurg. Psychiatr.. 2012 Sep 1;83(9):923-6.
BackgroundAmyloid imaging provides in vivo detection of the fibrillar amyloid-β (Aβ) plaques of Alzheimer's disease (AD). The positron emission tomography (PET) ligand, Pittsburgh Compound-B (PiB-C11), is the most well studied amyloid imaging agent, but the short half-life of carbon-11 limits its clinical viability. Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11.MethodsFourteen cognitively normal adults and 12 AD patients underwent PiB-C11 and florbetapir-F18 PET scans within a 28-day period.ResultsBoth ligands displayed highly significant group discrimination and correlation of regional uptake.ConclusionThese data support the hypothesis that florbetapir-F18 provides comparable information with PiB-C11.
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