• Bianca Pineda, Colin Kosinski, Nam Kim, Shabbar Danish, and William Craelius.
• Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
• Acta Neurochir. Suppl. 2018 Jan 1; 126: 297-301.

ObjectiveFollowing brain injury, unstable cerebral hemodynamics can be characterized by abnormal rises in intracranial pressure (ICP). This behavior has been quantified by the RAP index: the correlation (R) between ICP pulse amplitude (A) and mean (P). While RAP could be a valuable indicator of autoregulatory processes, its prognostic ability is not well established and its validity has been questioned due to potential errors in measurement. Here, we test (1) whether RAP is a consistent measure of intracranial hemodynamics and (2) whether RAP has prognostic value in predicting hemodynamic instability following brain injury.Materials And MethodsRAP was tested in seven brain injured patients treated in a surgical intensive care unit. A sample of ICP data was randomly chosen and segmented into 1 hour periods. Hours were then categorized as either stable, which contained no sharp rises in ICP, or unstable, which contained ≥1 sharp rise-where a sharp rise is defined as ICP exceeding a mean slope of 0.15 mmHg/s. Equal numbers of stable and unstable segments were then selected for each patient. RAP was calculated as the Pearson's correlation coefficient between ICP pulse amplitude (AMP) and mean (mICP), determined in 6 second windows, according to established methods.ResultsResults showed that (1) average AMP and ICP levels were similar between stable and unstable periods and (2) unstable periods were identified by RAP values exceeding 0.6 with an average positive predictive value of 74%.ConclusionsWe conclude that RAP can provide a valid measure of ICP dynamics, is not affected by sensor drift, and can better distinguish periods of instability than ICP or AMP alone.

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