• Emina Karahmet, Besim Prnjavorac, Tamer Bego, Adaleta Softić, Lejla Begić, Edin Begić, Esma Karahmet, Lejla Prnjavorac, and Irfan Prnjavorac.
• Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina.
• Med Glas (Zenica). 2021 Feb 1; 18 (1): 12-17.

AbstractAim To investigate interleukin 6 (IL-6) values depending on duration of diabetes mellitus (DM) and evaluate possible correlation with diabetic polyneuropathy. Methods The research study included 90 patients with DM divided into three groups (30 patients each) according to the duration of DM: group A - patients who had DM for less than 10 years, group B - duration of DM was 10 to 20 years, and group C - patients with DM over 20 years. Control group (K) included 30 healthy participants. Results IL-6 was significantly higher in the healthy control group, 180.318 pg/mL±94.18, than in group A, 47.23pg/ml±34.8, group B, 43.31pg/ml±33.17, and group C, 70.39 pg/ml±59.26 (p=0.0001). All groups had significantly different values of IL-6 between each other (p=0.0001). Level of IL-6 was in correlation with diabetic polyneuropathy in the group A (the youngest participants) (p=0.0001). In other groups there was no significant correlation between IL-6 and diabetic polyneuropathy. Conclusion The level of IL-6 was in correlation with neuropathy among younger patients. A higher level of IL-6 in the control group than in diabetic groups is a sign of stronger inflammatory response among younger and healthy people than in patients with DM.Copyright© by the Medical Assotiation of Zenica-Doboj Canton.

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