• D L M Oterdoom, J M Klaase, J Jobsen, R Bezooijen, and M H Coppes.
• Universitair Medisch Centrum Groningen, afd. Neurochirurgie, Groningen.
• Ned Tijdschr Geneeskd. 2008 May 17; 152 (20): 1129-35.

AbstractThree patients with a medical history of malignancy were referred for back pain: two women aged 53 and 43 years respectively, with breast cancer, and a woman of 85 years with rectal carcinoma. All patients suffered from spinal metastasis. Considerable delay occurred between the initial complaint of back pain and the diagnosis. This adversely influenced the outcome after treatment. A reliable differentiation, based on symptoms and signs, between widely occurring non-malignant back pain and back pain due to spinal metastasis is impossible. This confronts physicians with the dilemma of overexposing their patients to diagnostic tests on the one hand and the risk of missing an important diagnosis on the other. Early recognition of warning signs, i.e. previous medical history of malignancy, onset of back pain above 50 years of age, continuous pain not related to posture or movement and nocturnal pain, should alert physicians.

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