• Benjamin E Stein, Hamid Hassanzadeh, Amit Jain, Mesfin A Lemma, David B Cohen, and Khaled M Kebaish.
• From the Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD.
• Spine. 2014 Jul 1;39(15):1178-82.

Study DesignRetrospective data analysis.ObjectiveTo compare the trends in primary cervical spine fusion procedures in patients with rheumatoid arthritis (RA) against those in the general population.Summary Of Background DataRA severely impacts multiple joints in the body and can result in substantial deformity and functional impairment. Cervical spine involvement is common. In the past decade, treatment for RA has changed substantially with the introduction of biologically based, disease-modifying antirheumatic medications. Recent literature has shown decreasing rates of total joint arthroplasty in patients with RA.MethodsCases of cervical spine fusion in the general population and in patients with RA were identified from the Nationwide Inpatient Sample from 1992 through 2008. US population counts were obtained from the Census Bureau. Data were analyzed with computer software (significance, P < 0.05 for all analyses). Linear regression models were used to describe national rates of cervical spine fusion in patients with and without RA.ResultsThere was a marked increase in the number of cervical fusion procedures in the studied population. Over time, the incidence of atlantoaxial fusion increased in the general population (P < 0.01) and decreased in patients with RA (P < 0.01). Compared with the general population, patients with RA had a significantly lower rate of increase in the incidence of posterior cervical fusion (P < 0.01) and a significantly higher rate of increase in the incidence of anterior cervical fusion (P < 0.01).ConclusionIn the US, the absolute number of primary cervical fusion procedures from 1992 through 2008 increased in the general population and in patients with RA. However, the patients with RA had a significantly lower incidence of undergoing atlantoaxial and posterior cervical surgical procedures than did the general population.Level Of Evidence2.

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