• Ji Hyuk Lee, Heon Seok Han, and Joon Kee Lee.
• Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea.
• J. Korean Med. Sci. 2021 Jan 11; 36 (2): e17e17.

AbstractIn April 2020, a pediatric report of an unusual inflammatory illness associated with coronavirus disease 2019 (COVID-19) led to similar cases in Europe and North America, which was referred to as multisystem inflammatory syndrome in children (MIS-C). Herein, we describe the case of a 12-year-old boy who had a history of polymerase chain reaction-confirmed COVID-19 and developed MIS-C approximately three weeks after an initial diagnosis of COVID-19. High fever with abdominal pain mimicking appendicitis was the initial manifestation of MIS-C, which could have been easily missed if the patient's history of COVID-19 was ignored. Intravenous immunoglobulin was administered twice, 24 hours apart, five days after the onset of MIS-C, and the patient fully recovered without any obvious sequelae. Early recognition by disease awareness and prompt management are the keys to saving the lives of children affected by MIS-C.© 2021 The Korean Academy of Medical Sciences.

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