• Rachael L Parke, Eileen Gilder, Michael J Gillham, Laurence J C Walker, Michael J Bailey, Shay P McGuinness, and Fluids After Bypass Study Investigators.
• Cardiothoracic and Vascular ICU, Auckland City Hospital, Auckland, New Zealand.
• Crit. Care Med. 2021 Mar 1; 49 (3): 449-461.

ObjectivesThere is little evidence to guide fluid administration to patients admitted to the ICU following cardiac surgery. This study aimed to determine if a protocolized strategy known to reduce fluid administration when compared with usual care reduced ICU length of stay following cardiac surgery.DesignProspective, multicenter, parallel-group, randomized clinical trial.SettingFive cardiac surgical centers in New Zealand conducted from November 2016 to December 2018 with final follow-up completed in July 2019.PatientsSeven-hundred fifteen patients undergoing cardiac surgery; 358 intervention and 357 usual care.InterventionsRandomization to protocol-guided strategy utilizing stroke volume variation to guide administration of bolus fluid or usual care fluid administration until desedation or up to 24 hours. Primary outcome was length of stay in ICU. Organ dysfunction, mortality, process of care measures, patient-reported quality of life, and disability-free survival were collected up to day 180.Measurements And Main ResultsOverall 666 of 715 (93.1%) received at least one fluid bolus. Patients in the intervention group received less bolus fluid (median [interquartile range], 1,000 mL [250-2,000 mL] vs 1,500 mL [500-2,500 mL]; p < 0.0001) and had a lower overall fluid balance (median [interquartile range], 319 mL [-284 to 1,274 mL] vs 673 mL [38-1,641 mL]; p < 0.0001) in the intervention period. There was no difference in ICU length of stay between the two groups (27.9 hr [21.8-53.5 hr] vs 25.6 hr [21.9-64.6 hr]; p = 0.95). There were no differences seen in development of organ dysfunction, quality of life, or disability-free survival at any time points. Hospital mortality was higher in the intervention group (4% vs 1.4%; p = 0.04).ConclusionsA protocol-guided strategy utilizing stroke volume variation to guide administration of bolus fluid when compared with usual care until desedation or up to 24 hours reduced the amount of fluid administered but did not reduce the length of stay in ICU.Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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