• Cancer discovery · Jun 2020

    Review

    TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

    • Konrad H Stopsack, Lorelei A Mucci, Emmanuel S Antonarakis, Peter S Nelson, and Philip W Kantoff.
    • Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    • Cancer Discov. 2020 Jun 1; 10 (6): 779-782.

    AbstractTMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.©2020 American Association for Cancer Research.

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