• Meysam Abolmaali, Matineh Heidari, Marjan Zeinali, Parichehr Moghaddam, Mona Ramezani Ghamsari, Mahin Jamshidi Makiani, and Zahra Mirzaasgari.
• Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
• J Clin Neurosci. 2021 Jan 1; 83: 119-122.

AbstractThe global SARS-CoV-2 pandemic posed an unprecedented challenge to almost all fields of medicine and Neurology is not an exception. Collecting information about its complications and related conditions will help clinicians to become more confident in managing this disease. Guillain-Barre Syndrome (GBS) is mostly described as a post-infectious phenomenon and its occurrence during acute phase of illness is of interest. GBS has recently been reported during the active phase of COVID-19 for the first time. Severity and fast progression of GBS associated with COVID-19 have also been shown in recent studies. Here we report three cases of GBS during the active phase of COVID-19 with severe symptoms and fast progression to quadriplegia and facial diplegia over 2 days, which led to death in one case due to severe autonomic dysfunction. We suggest SARS-CoV-2 might be associated with rather a severe, rapidly progressive and life-threatening phenotype of GBS.Copyright © 2020 Elsevier Ltd. All rights reserved.

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