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Neurosci Biobehav Rev · Dec 2020
ReviewNeurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses.
- Jingman Hu, Jukka Jolkkonen, and Chuansheng Zhao.
- Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, PR China.
- Neurosci Biobehav Rev. 2020 Dec 1; 119: 184-193.
AbstractA novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the central nervous system (CNS), especially those critically ill ones. In this review, we will discuss how SARS-CoV-2 gain access to the CNS and the possible consequences. Both SARS-CoV-2 and SARS-CoV-1 in 2002 share the same receptor angiotensin-converting enzyme 2 (ACE2), which can be found in the brain and mediate the disease process. Both direct attack of SARS-CoV-2 and the abnormal immune response in the CNS would contribute to the disease. Also, there is a relationship between SARS-CoV-2 and the occurrence of acute cerebrovascular diseases.Copyright © 2020 Elsevier Ltd. All rights reserved.
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