• Journal of oral science · Mar 2014

    Effect of basic fibroblast growth factor on angiogenesis and bone regeneration in non-critical-size bone defects in rat calvaria.

    • Risa Kigami, Shuichi Sato, Noriko Tsuchiya, Nobuaki Sato, Daigo Suzuki, Yoshinori Arai, Koichi Ito, and Bunnai Ogiso.
    • Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry.
    • J Oral Sci. 2014 Mar 1; 56 (1): 17-22.

    AbstractWe used microcomputed tomography (micro-CT) to evaluate the effects of basic fibroblast growth factor (FGF-2) contained in absorbable collagen sponges on angiogenesis and bone regeneration in rat calvarial non-critical-size bone defects. Two symmetrical non-critical-size calvarial bone defects (diameter, 2.7 mm) were created in male Fisher rats. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each defect. Blood vessel volume and bone volume were calculated using software. On day 28, blood vessel volume and bone volume were significantly greater in the 0.3% and 0.1% FGF-2 groups than in the control group. FGF-2 concentration-dependently increased blood vessels and bone formation in non-critical-size bone defects in rat calvaria.

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