• Minglong Chen, Kai Gu, Bing Yang, Hongwu Chen, Weizhu Ju, Fengxiang Zhang, Gang Yang, Mingfang Li, Xinzheng Lu, Kejiang Cao, and Feifan Ouyang.
• From the Division of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.C., K.G., B.Y., H.C., W.J., F.Z., G.Y., M.L., X.L., K.C.); and II Medizinische Abteilung, Allgemeines Krankenhaus St. Georg, Hamburg, Germany (F.O.). chenminglong@njmu.edu.cn.
• Circ Arrhythm Electrophysiol. 2014 Dec 1; 7 (6): 1159-67.

BackgroundAccelerated idioventricular rhythm (AIVR) or ventricular tachycardia (VT) originating from the right bundle branch (RBB) is rare and published clinical data on such arrhythmia are scarce. In this study, we will describe the clinical manifestations, diagnosis, and management of a cohort of patients with this novel arrhythmia.Methods And ResultsEight patients (5 men; median age, 25 years) with RBB-AIVR/VT were consecutively enrolled in the study. Pharmacological testing, exercise treadmill testing, electrophysiological study, and catheter ablation were performed in the study patients, and ECG features were characterized. All RBB-AIVR/VTs were of typical left bundle-branch block morphology with atrioventricular dissociation. The arrhythmias, which demonstrated chronotropic variability, were often isorhythmic with sinus rhythm and were accelerated by physical exercise, stress, and intravenous isoprenaline infusion. The rate of RBB-AIVR/VT varied from 45 to 200 beats per minute. Two patients experienced syncope, and 3 had impaired left ventricular function. Metoprolol was proven to be the most effective drug to decelerate the arrhythmia rate and relieve symptoms. Electrophysiology study was performed in 5 patients and the earliest activation with a sharp RBB potential was localized in the mid or distal RBB area. Catheter ablation terminated the arrhythmia with subsequent RBB block morphology during sinus rhythm. During follow-up, patients' symptoms were controlled with normalization of left ventricular function either on metoprolol or by catheter ablation.ConclusionsRBB-AIVR/VT is an unusual type of ventricular arrhythmia. It can result in significant symptoms and depressed ventricular function and can be successfully treated with catheter ablation.© 2014 American Heart Association, Inc.

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