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- Ana Furtado Lima, José Reis, Fátima Serrano, and Augusta Borges.
- Serviço de Medicina Materno-Fetal, Maternidade Dr. Alfredo da Costa, Lisboa.
- Acta Medica Port. 2010 Jul 1; 23 (4): 727-30.
AbstractThe authors report a clinical case of warfarin hypersensitivity noticed when a patient, with thromboembolic risk, was submitted to warfarin. She was found to be heterozigotic to -1639G>A (gene VKORC1) and homozygotic to 1075A>C (genotype CYP2C9*3/*3). In this article the warfarin pharmacodinamics and its role over Vitamin K is revisited. It includes some suggested indications for investigating genetic polymorphisms, in order to avoid complications associated with warfarin.
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