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- Qingyang Zhang, Jieming Ping, Zirui Huang, Xiaoli Zhang, Jingyi Zhou, Gangyang Wang, Shaoyang Liu, and Jianjun Ma.
- Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan 453003, China.
- J Immunol Res. 2020 Jan 1; 2020: 1924379.
AbstractChimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. This review mainly describes the toxicity of CAR-T cell therapy and the challenges of CAR-T cells in the treatment of solid tumors, and looks forward to future development and opportunities for immunotherapy and reviews major breakthroughs in CAR-T cell therapy.Copyright © 2020 Qingyang Zhang et al.
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