• The lancet oncology · Feb 2021

    Review

    Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group.

    • Renée L Mulder, Anna Font-Gonzalez, Daniel M Green, Loeffen Erik A H EAH Department of Pediatric Oncology/Hematology, Beatrix Children's Hospital, UMC Groningen, University of Groningen, Groningen, Netherlands., Melissa M Hudson, Jacqueline Loonen, Richard Yu, Jill P Ginsberg, Rod T Mitchell, Julianne Byrne, Roderick Skinner, Antoinette Anazodo, Louis S Constine, Andrica de Vries, Kirsi Jahnukainen, Armando Lorenzo, Andreas Meissner, Leena Nahata, Marij Dinkelman-Smit, Herman Tournaye, Riccardo Haupt, Marry M van den Heuvel-Eibrink, Hanneke M van Santen, van Pelt Ans M M AMM Laboratory for Reproductive Biology, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Uta Dirksen, Jaap den Hartogh, Eline van Dulmen-den Broeder, W Hamish Wallace, Jennifer Levine, Tissing Wim J E WJE Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology/Hematology, Beatrix Children's Hospital, UMC Gro, Kremer Leontien C M LCM Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Pediatric Oncology, Emma Children's Hospital, Amsterdam University, Amsterdam, Lisa B Kenney, Marianne D van de Wetering, and PanCareLIFE Consortium.
    • Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Electronic address: r.l.mulder@prinsesmaximacentrum.nl.
    • Lancet Oncol. 2021 Feb 1; 22 (2): e57-e67.

    AbstractMale patients with childhood, adolescent, and young adult cancer are at an increased risk for infertility if their treatment adversely affects reproductive organ function. Future fertility is a primary concern of patients and their families. Variations in clinical practice are barriers to the timely implementation of interventions that preserve fertility. As part of the PanCareLIFE Consortium, in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in male patients who are diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the available evidence and to form the recommendations. Recognising the need for global consensus, this clinical practice guideline used existing evidence and international expertise to rigorously develop transparent recommendations that are easy to use to facilitate the care of male patients with childhood, adolescent, and young adult cancer who are at high risk of fertility impairment and to enhance their quality of life.Copyright © 2021 Elsevier Ltd. All rights reserved.

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