• The lancet oncology · Feb 2021

    Review

    Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group.

    • Renée L Mulder, Anna Font-Gonzalez, Eline van Dulmen-den Broeder, Gwendolyn P Quinn, Jill P Ginsberg, Loeffen Erik A H EAH Department of Pediatric Oncology/Hematology, Beatrix Children's Hospital, UMC Groningen, University of Groningen, Groningen, Netherlands., Melissa M Hudson, Karen C Burns, Hanneke M van Santen, Claire Berger, Tamara Diesch, Uta Dirksen, Aleksander Giwercman, Clarisa Gracia, Sarah E Hunter, Joanne F Kelvin, James L Klosky, Laven Joop S E JSE Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, Netherlands., Barbara A Lockart, Neggers Sebastian J C M M SJCMM Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Sophia Children's Hospital and Pituitary Center Rotterdam, Endocrinol, Michelle Peate, Bob Phillips, Damon R Reed, Eva Maria E Tinner, Julianne Byrne, Margreet Veening, Marleen van de Berg, Chris M Verhaak, Antoinette Anazodo, Kenny Rodriguez-Wallberg, Marry M van den Heuvel-Eibrink, Ogechukwu A Asogwa, Alexandra Brownsdon, W Hamish Wallace, Daniel M Green, Roderick Skinner, Riccardo Haupt, Lisa B Kenney, Jennifer Levine, Marianne D van de Wetering, Tissing Wim J E WJE Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology/Hematology, Beatrix Children's Hospital, UMC Gro, Norbert W Paul, Kremer Leontien C M LCM Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Am, Julia Inthorn, and PanCareLIFE Consortium.
    • Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Electronic address: r.l.mulder@prinsesmaximacentrum.nl.
    • Lancet Oncol. 2021 Feb 1; 22 (2): e68-e80.

    AbstractPatients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families. Moreover, the guideline panel formulated considerations of the ethical implications that are associated with these procedures. Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the evidence and recommendations. In this clinical practice guideline, existing evidence and international expertise are combined to develop transparent recommendations that are easy to use to facilitate ongoing communication between health-care providers and patients with childhood, adolescent, and young adult cancer who might be at high risk for fertility impairment and their families.Copyright © 2021 Elsevier Ltd. All rights reserved.

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