• Nan-Chang Chiu, Hsin Chi, Yu-Lin Tai, Chun-Chih Peng, Cheng-Yin Tseng, Chung-Chu Chen, Boon Fatt Tan, and Chien-Yu Lin.
• MacKay Children's Hospital, Taipei, Taiwan.
• J. Med. Internet Res. 2020 Aug 20; 22 (8): e21257.

BackgroundThe coronavirus disease (COVID-19) pandemic is an important health crisis worldwide. Several strategies were implemented to combat COVID-19, including wearing masks, hand hygiene, and social distancing. The impact of these strategies on COVID-19 and other viral infections remains largely unclear.ObjectiveWe aim to investigate the impact of implemented infectious control strategies on the incidences of influenza, enterovirus infection, and all-cause pneumonia during the COVID-19 pandemic.MethodsWe utilized the electronic database of the Taiwan National Infectious Disease Statistics System and extracted incidences of COVID-19, influenza virus, enterovirus, and all-cause pneumonia. We compared the incidences of these diseases from week 45 of 2016 to week 21 of 2020 and performed linear regression analyses.ResultsThe first case of COVID-19 in Taiwan was reported in late January 2020 (week 4). Infectious control strategies have been promoted since late January. The influenza virus usually peaks in winter and decreases around week 14. However, a significant decrease in influenza was observed after week 6 of 2020. Regression analyses produced the following results: 2017, R2=0.037; 2018, R2=0.021; 2019, R2=0.046; and 2020, R2=0.599. A dramatic decrease in all-cause pneumonia was also reported (R2 values for 2017-2020 were 0.435, 0.098, 0.352, and 0.82, respectively). Enterovirus had increased by week 18 in 2017-2019, but this was not observed in 2020.ConclusionsUsing this national epidemiological database, we found a significant decrease in cases of influenza, enterovirus, and all-cause pneumonia during the COVID-19 pandemic. Wearing masks, hand hygiene, and social distancing may contribute not only to the prevention of COVID-19 but also to the decline of other respiratory infectious diseases. Further studies are warranted to elucidate the causal relationship.©Nan-Chang Chiu, Hsin Chi, Yu-Lin Tai, Chun-Chih Peng, Cheng-Yin Tseng, Chung-Chu Chen, Boon Fatt Tan, Chien-Yu Lin. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 20.08.2020.

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