• Pether Jildenstål, Daniel Widarsson Norbeck, Johan Snygg, Sven-Erik Ricksten, and Lukas Lannemyr.
• Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
• Paediatr Anaesth. 2021 May 1; 31 (5): 563-569.

BackgroundData on cerebral pressure-flow autoregulation in the youngest children are scarce. We studied the correlation between mean arterial pressure and cerebral tissue oxygen saturation (rSO2 ) by near-infrared spectroscopy (NIRS) in patients undergoing nose, lip, and palate surgery.AimWe tested the hypothesis that cerebral pressure-flow autoregulation is impaired in children less than 1 year undergoing surgery and general anesthesia with sevoflurane under controlled mechanical ventilation.MethodAfter approval from the Ethical board, 15 children aged <1 year were included. Before anesthesia induction, a NIRS sensor (INVOSTM , Medtronic, Minneapolis, USA) was placed over the cerebral frontal lobe. Frontal rSO2 , a surrogate for cerebral perfusion, mean arterial pressure, end-tidal CO2 - and sevoflurane concentration, and arterial oxygen saturation were sampled every minute after the induction. A repeated measures correlation analysis was performed to study correlation between mean arterial pressure and cerebral rSO2 , and the repeated measures correlation coefficient (rrm ) was calculated.ResultsFifteen patients, aged 7.7 ± 1.9 months, were studied. rSO2 showed a positive correlation with mean arterial pressure ([95% CI: 9.0-12.1], P < 0.001) with a moderate to large effect size (rrm  = 0.462), indicating an impaired cerebral pressure-flow autoregulation. The slopes of the rSO2 -mean arterial pressure correlations were steeper in patients who were hypotensive (mean arterial pressure <50 mm Hg) compared to patients having a mean arterial pressure ≥50 mm Hg, indicating that at lower mean arterial pressure, the cerebral pressure dependence of cerebral oxygenation is even more pronounced.ConclusionDuring sevoflurane anesthesia in the youngest pediatric patients, cerebral perfusion is pressure-dependent, suggesting that the efficiency of the cerebral blood flow autoregulation is limited.© 2021 The Authors. Pediatric Anesthesia published by John Wiley & Sons Ltd.

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