• Konrad Schmidt, Jochen Gensichen, Carolin Fleischmann-Struzek, Viola Bahr, Christine Pausch, Yasser Sakr, Konrad Reinhart, Horst Christian Vollmar, Paul Thiel, André Scherag, Julia Gantner, and Frank M Brunkhorst.
• Center for Sepsis Control and Care (CSCC), Jena University Hospital; Institute of General Practice and Family Medicine, Jena University Hospital; Institute of General Practice, Charité-Universitätsmedizin Berlin; Institute of General Practice and Family Medicine, Munich University Hospital, Ludwig-Maximilians-Universität München; Center for Clinical Studies, Jena University Hospital; Clinic for Anaesthesiology and Intensive Care Medicine, Jena University Hospital; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University; Institute of General Practice and Family Medicine, Ruhr-University Bochum; Institute of Medical Statistics, Computer Science and Data Sciences, Jena University Hospital.
• Dtsch Arztebl Int. 2020 Nov 13; 117 (46): 775782775-782.

BackgroundThere have not yet been any prospective registry studies in Germany with active investigation of the long-term survival of patients with sepsis.MethodsThe Jena Sepsis Registry (JSR) included all patients with a diagnosis of sepsis in the four intensive care units of Jena University Hospital from January 2011 to December 2015. Long-term survival 6-48 months after diagnosis was documented by asking the treating general practitioners. The survival times were studied with Kaplan-Meier estimators. Cox regressions were calculated to show associations between possible predictors and survival time.Results1975 patients with sepsis or septic shock were included. The mean time of observation was 730 days. For 96.4% of the queries to the general practitioners, information on long-term survival was available. Mortality in the intensive care unit was 34% (95% confidence interval [32; 37]), and in-hospital mortality was 45% [42; 47]. The overall mortality six months after diagnosis was 59% [57; 62], the overall mortality 48 months after diagnosis was 74% [72; 78]. Predictors of shorter survival were age, nosocomial origin of sepsis, diabetes, cerebrovascular disease, duration of stay in the intensive care unit, and renal replacement therapy.ConclusionThe nearly 75% mortality four years after diagnosis indicates that changes are needed both in the acute treatment of patients with sepsis and in their multi-sector long-term care. The applicability of these findings may be limited by their having been obtained in a single center.

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