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- Xiulu Ruan, Ken F Mancuso, and Alan D Kaye.
- Department of Anesthesiology, Louisiana State University Health Science Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA. Electronic address: drxruan88@gmail.com.
- Anesthesiol Clin. 2017 Jun 1; 35 (2): e163-e174.
AbstractOxycodone, a semisynthetic opioid analgesic, is widely used in clinical practice. Oxycodone and morphine seem to be equally effective and equipotent; however, morphine is 10 times more potent than oxycodone when given epidurally. This article provides an updated review of the basic pharmacology of oxycodone with a special focus on pharmacokinetic/pharmacodynamics properties. The controversy regarding oxycodone-mediated effects for visceral pain via agonism and the possible role of peripheral opioid analgesia are discussed in the present investigation in an attempt to propose a plausible explanation to the perplexing question of oxycodone analgesia.Copyright © 2017 Elsevier Inc. All rights reserved.
This article appears in the collection: Oxycodone.
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