• Int J Clin Exp Patho · Jan 2015

    The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer.

    • Wang-Yang Chen, Xiao-Juan Zhao, Zhi-Fu Yu, Fu-Lan Hu, Yu-Peng Liu, Bin-Bin Cui, Xin-Shu Dong, and Ya-Shuang Zhao.
    • Department of Epidemiology, Public Health College, Harbin Medical University Harbin, Heilongjiang 150081, P. R. China.
    • Int J Clin Exp Patho. 2015 Jan 1; 8 (6): 7092-101.

    AbstractCirculating microRNAs (miRNAs) were recognized to be potential non-invasive biomarkers for colorectal cancer (CRC) detection and prediction. Meanwhile, the association of the expression of plasma miRNAs with the risk of CRC patients has rarely been analyzed. Therefore, we conducted this study to evaluate the value of plasma miRNAs for CRC diagnosis and risk estimation. Fasting blood samples from 100 CRC patients and 79 cancer-free controls were collected. Plasma miR-106a, miR-20a, miR-27b, miR-92a and miR-29a levels were detected by RT-qPCR. Sensitivity and specificity were employed to evaluate the diagnostic value of miRNAs for CRC. Univariate and multivariate logistic regression were employed to analyze the association between miRNAs expression and CRC risk. As results, miR-106a and miR-20a were elevated in the patients with CRC. The sensitivity of miR-106a was 74.00% and the specificity was 44.40%, while the cutoff value was 2.03. As for miR-20a, the sensitivity was 46.00% and specificity was 73.42% when employed 2.44 as cutoff value. High expression of plasma miR-106a increased CRC risk by 1.80 -fold. Plasma miR-106a and miR-20a may as noninvasive biomarkers for detecting the CRC. High expression of miR-106a associated with CRC risk.

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