• Scot Med J · Feb 2021

    Irreversible electroporation ablation against subcutaneously implanted VX2 tumors in rabbits: findings of shearwave ultrasound elastography.

    • Rui Chen, Sheng Li, Limei Wu, Xueyan Qiao, Yanhua Luo, Xiaohua Zhou, Shaodong Qiu, and Fei Chen.
    • Attending Doctor, Department of Ultrasound, the Second Affiliated Hospital of Guangzhou Medical University, China.
    • Scot Med J. 2021 Feb 1; 66 (1): 23-28.

    PurposeThis study aimed to evaluate stiffness changes of rabbit subcutaneous VX2 tumors before and after irreversible electroporation (IRE) ablationby shearwave ultrasound elastography (SWE).MethodsIRE was performed on 20 subcutaneously implanted VX2 tumors in rabbits (R-SIVX2). Tumor stiffness was measured by SWE at different time points (before IRE,120minutes after IRE,7 days after IRE and 14 days after IRE).ResultsBefore IRE, the mean stiffness (Emean) of tumors was (10.45 ± 1.07) KPa. 120 minutes after I RE, the Emean of tumors obviously rose to (70.53 ± 9.87) KPa. 7 days after IRE, the Emean of tumors decreased to (40.22 ± 9.01) KPa. 14 days after IRE, the Emean of tumors was (15.17 ± 1.00) KPa. A clear boundary was observed between the ablation area and the normal tissues in the pathological results.ConclusionsThe stiffness of the VX2 tumors experienced a first rise process and tend to be normal in the procedure of IRE. SWE could provide tissue stiffness information of different IRE ablation period as a non-invasive method.

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